Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice
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چکیده
منابع مشابه
Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)
Two cyclooxygenase isozymes catalyze conversion of arachidonic acid to prostaglandin H2: constitutive COX-1 and inducible COX-2. To assess the role of COX-2 in colorectal tumorigenisis, we determined the effects of COX-2 gene (Ptgs2) knockouts and a novel COX-2 inhibitor on Apc delta716 knockout mice, a model of human familial adenomatous polyposis. A Ptgs2 null mutation reduced the number and ...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2001
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm0901-1048